APC2 is critical for ovarian WNT signalling control, fertility and tumour suppression.

ABSTRACT:

Background

Canonical WNT signalling plays a critical role in the regulation of ovarian development; mis-regulation of this key pathway in the adult ovary is associated with subfertility and tumourigenesis. The roles of Adenomatous polyposis coli 2 (APC2), a little-studied WNT signalling pathway regulator, in ovarian homeostasis, fertility and tumourigenesis have not previously been explored. Here, we demonstrate essential roles of APC2 in regulating ovarian WNT signalling and ovarian homeostasis.

Methods

A detailed analysis of ovarian histology, gene expression, ovulation and hormone levels was carried out in 10 week old and in aged constitutive APC2-knockout (Apc2^-/-) mice (mixed background). Statistical significance for qRT-PCR data was determined from 95% confi

SUBMITTER: Mohamed NE 

PROVIDER: S-EPMC6617595 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature