Comparative efficacy of linezolid and vancomycin for endotracheal tube MRSA biofilms from ICU patients.

ABSTRACT:

Purpose

To compare the efficacy of systemic treatment with linezolid (LNZ) versus vancomycin (VAN) on methicillin-resistant Staphylococcus aureus (MRSA) burden and eradication in endotracheal tube (ETT) biofilm and ETT cuff from orotracheally intubated patients with MRSA respiratory infection.

Methods

Prospective observational clinical study was carried out at four European tertiary hospitals. Plasma and endotracheal aspirate (ETA) levels of LNZ and VAN were determined 72 h after treatment initiation through high-performance liquid chromatography or bioassay. LNZ or VAN concentration in the ETT biofilm and MRSA burden and eradication was determined upon extubation. The minimum inhibitory concentration (MIC) for LNZ and VAN was assessed by E-test strips (Biomerieux®). Scannin

SUBMITTER: Fernandez-Barat L 

PROVIDER: S-EPMC6617612 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature