Urinary nephrospheres indicate recovery from acute kidney injury in renal allograft recipients - a pilot study.

ABSTRACT:

Background

Acute kidney injury represents a major threat to the transplanted kidney. Nevertheless, these kidneys have the potential to fully recover. Tubular regeneration following acute kidney injury is driven by the regenerative potential of tubular cells originating from a tubular stem cell pool. We investigated urinary sediments of acute kidney injury transplanted patients and compared it to those of non-transplanted patients. Thereby we discovered tubular cell agglomerates, which have not been described in vivo. We hypothesized that these so-called nephrospheres were associated with recovery from acute kidney injury.

Methods

Urine sediment of 45 kidney-transplanted and 19 non-transplanted individuals was investigated. Nephrospheres were isolated and stained for several

SUBMITTER: Knafl D 

PROVIDER: S-EPMC6617660 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature