Molecular clustering of genes related to the atopic syndrome: Towards a more tailored approach and personalized medicine?

ABSTRACT:

Background

The atopic syndrome consists of heterogeneous manifestations, in which multiple associated genetic loci have recently been identified. It is hypothesized that immune dysregulation plays a role in the pathogenesis. In primary immunodeficiency diseases (PIDs), which are often monogenic immunodysregulation disorders, the atopic syndrome is a frequently occurring comorbidity. Based on the genetic defects in PIDs, novel gene/pathway-targeted therapies have been evaluated, which could be relevant in the atopic syndrome as well. Therefore, we aimed to define subclasses within the atopic syndrome based on the expression profiles of immune cell lineages of healthy mice.

Methods

Overlap between known atopy-related genes as described in the Human Gene Mutation Database and d

SUBMITTER: de Wit J 

PROVIDER: S-EPMC6617681 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature