Cell type-specific epigenetic links to schizophrenia risk in the brain.

ABSTRACT:

Background

The importance of cell type-specific epigenetic variation of non-coding regions in neuropsychiatric disorders is increasingly appreciated, yet data from disease brains are conspicuously lacking. We generate cell type-specific whole-genome methylomes (N = 95) and transcriptomes (N = 89) from neurons and oligodendrocytes obtained from brain tissue of patients with schizophrenia and matched controls.

Results

The methylomes of the two cell types are highly distinct, with the majority of differential DNA methylation occurring in non-coding regions. DNA methylation differences between cases and controls are subtle compared to cell type differences, yet robust against permuted data and validated in targeted deep-sequencing analyses. Differential DNA methylation between c

SUBMITTER: Mendizabal I 

PROVIDER: S-EPMC6617737 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature