Impact of resection margin status on recurrence and survival in pancreatic cancer surgery.

ABSTRACT: BACKGROUND:The prognosis of patients with pancreatic ductal adenocarcinoma (PDAC) is poor and selection of patients for surgery is challenging. This study examined the impact of a positive resection margin (R1) on locoregional recurrence (LRR) and overall survival (OS); and also aimed to identified tumour characteristics and/or technical factors associated with a positive resection margin in patients with PDAC. METHODS:Patients scheduled for pancreatic resection for PDAC between 2006 and 2016 were identified from an institutional database. The effect of resection margin status, patient characteristics and tumour characteristics on LRR, distant metastasis and OS was assessed. RESULTS:A total of 322 patients underwent pancreatectomy for PDAC. A positive resection (R1) margin was found in 129

SUBMITTER: Tummers WS 

PROVIDER: S-EPMC6617755 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature