Quantitative biokinetics over a 28 day period of freshly generated, pristine, 20 nm titanium dioxide nanoparticle aerosols in healthy adult rats after a single two-hour inhalation exposure.

ABSTRACT:

Background

Industrially produced quantities of TiO₂ nanoparticles are steadily rising, leading to an increasing risk of inhalation exposure for both professionals and consumers. Particle inhalation can result in inflammatory and allergic responses, and there are concerns about other negative health effects from either acute or chronic low-dose exposure.

Results

To study the fate of inhaled TiO₂-NP, adult rats were exposed to 2-h intra-tracheal inhalations of ⁴⁸V-radiolabeled, 20 nm TiO₂-NP aerosols (deposited NP-mass 1.4 ± 0.5 μg). At five time points (1 h, 4 h, 24 h, 7d, 28d) post-exposure, a complete balance of the [⁴⁸V]TiO₂-NP fate was quantified in organs, tissues, carcass, lavage and body fluids, includin

SUBMITTER: Kreyling WG 

PROVIDER: S-EPMC6617842 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature