The engineering principles of combining a transcriptional incoherent feedforward loop with negative feedback.

ABSTRACT:

Background

Regulation of gene expression is of paramount importance in all living systems. In the past two decades, it has been discovered that certain motifs, such as the feedforward motif, are overrepresented in gene regulatory circuits. Feedforward loops are also ubiquitous in process control engineering, and are nearly always structured so that one branch has the opposite effect of the other, which is a structure known as an "incoherent" feedforward loop in biology. In engineered systems, feedforward control loops are subject to several engineering constraints, including that (1) they are finely-tuned so that the system returns to the original steady state after a disturbance occurs (perfect adaptation), (2) they are typically only implemented in the combination with negative f

SUBMITTER: Reeves GT 

PROVIDER: S-EPMC6617889 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature