Joint effect of insulin signaling genes on insulin secretion and glucose homeostasis.

ABSTRACT:

Context

Reduced insulin signaling in insulin secreting β-cells causes defective insulin secretion and hyperglycemia in mice.

Objective

We investigated whether functional polymorphisms affecting insulin signaling (ie, ENPP1 K121Q, rs1044498; IRS1 G972R, rs1801278; and TRIB3 Q84R, rs2295490) exert a joint effect on insulin secretion and abnormal glucose homeostasis (AGH).

Design

Insulin secretion was evaluated by 1) the disposition index (DI) from an oral glucose tolerance test (OGTT) in 829 individuals; 2) insulin secretion stimulation index (SI) in islets from nondiabetic donors after glucose (n = 92) or glibenclamide (n = 89) stimulation. AGH (including impaired fasting glucose and/or impaired glucose tolerance or type 2 diabetes; T2D) was evaluated in case-control s

SUBMITTER: Prudente S 

PROVIDER: S-EPMC6618023 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature