Adipose Tissue Protein Glycoxidation is Associated with Weight-Loss Potential.

ABSTRACT: OBJECTIVE:This study aimed to characterize the differences in protein oxidation biomarkers in adipose tissue (AT) as an indicator of AT metabolism and bariatric surgery weight-loss success. METHODS:A human model, in which sixty-five individuals with obesity underwent bariatric surgery, and a diet-induced obesity animal model, in which animals were treated for 2 months with normocaloric diets, were analyzed to determine the associations between AT protein oxidation and body weight loss. Protein oxidative biomarkers were determined by gas chromatography/mass spectrometry in AT from human volunteers before the surgery, as well as 2 months after a diet treatment in the animal model. RESULTS:The levels of carboxyethyl-lysine (CEL) and 2-succinocystein (2SC) in both visceral and subcutaneous AT

SUBMITTER: Serrano JCE 

PROVIDER: S-EPMC6618070 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature