Determinants of Cytochrome P450 2D6 mRNA Levels in Healthy Human Liver Tissue.

ABSTRACT: Cytochrome P450 2D6 (CYP2D6) is a major drug-metabolizing enzyme that exhibits large interindividual variability. Recent studies suggest that differential transcriptional regulation of CYP2D6 in part may be responsible for the variability. In this study, we characterized potential determinants of CYP 2D6  transcript levels in healthy human liver tissue samples (n = 115), including genetic polymorphisms in CYP2D6 and the genes encoding transcription regulators for CYP2D6 expression; mRNA expression of the transcription factors and their known target genes; and hepatic levels of bile acids and retinoids, agents that modulate the expression/activity of the transcription factors. Their associations with CYP2D6 mRNA levels in the tissues were examined. Results from multivariable linear regressi

SUBMITTER: Ning M 

PROVIDER: S-EPMC6618095 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature