Validity of ICD-9 and ICD-10 codes used to identify acute liver injury: A study in three European data sources.

ABSTRACT:

Purpose

Validating cases of acute liver injury (ALI) in health care data sources is challenging. Previous validation studies reported low positive predictive values (PPVs).

Methods

Case validation was undertaken in a study conducted from 2009 to 2014 assessing the risk of ALI in antidepressants users in databases in Spain (EpiChron and SIDIAP) and the Danish National Health Registers. Three ALI definitions were evaluated: primary (specific hospital discharge codes), secondary (specific and nonspecific hospital discharge codes), and tertiary (specific and nonspecific hospital and outpatient codes). The validation included review of patient profiles (EpiChron and SIDIAP) and of clinical data from medical records (EpiChron and Denmark). ALI cases were confirmed when liver enzym

SUBMITTER: Forns J 

PROVIDER: S-EPMC6618105 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature