Reproducibility of a battery of human evoked pain models to detect pharmacological effects of analgesic drugs.

ABSTRACT:

Background

Although reproducibility is considered essential for any method used in scientific research, it is investigated only rarely; thus, strikingly little has been published regarding the reproducibility of evoked pain models involving human subjects. Here, we studied the reproducibility of a battery of evoked pain models for demonstrating the analgesic effects of two analgesic compounds.

Methods

A total of 81 healthy subjects participated in four studies involving a battery of evoked pain tests in which mechanical, thermal and electrical stimuli were used to measure pain detection and tolerance thresholds. Pharmacodynamic outcome variables were analysed using a mixed model analysis of variance, and a coefficient of variation was calculated by dividing the standard devi

SUBMITTER: Siebenga PS 

PROVIDER: S-EPMC6618124 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature