Interleukin-6 in the central amygdala is bioactive and co-localised with glucagon-like peptide-1 receptor.

ABSTRACT: Neuronal circuits involving the central amygdala (CeA) are gaining prominence as important centres for regulation of metabolic functions. As a part of the subcortical food motivation circuitry, CeA is associated with food motivation and hunger. We have previously shown that interleukin (IL)-6 can act as a downstream mediator of the metabolic effects of glucagon-like peptide-1 (GLP-1) receptor (R) stimulation in the brain, although the sites of these effects are largely unknown. In the present study, we used the newly generated and validated RedIL6 reporter mouse strain to investigate the presence of IL-6 in the CeA, as well as possible interactions between IL-6 and GLP-1 in this nucleus. IL-6 was present in the CeA, mostly in cells in the medial and lateral parts of this structure, and a m

SUBMITTER: Anesten F 

PROVIDER: S-EPMC6618171 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature