Acid sensing ion channel 2: A new potential player in the pathophysiology of multiple sclerosis.

ABSTRACT: Acid-sensing ion channels (ASICs) are proton-gated channels involved in multiple biological functions such as: pain modulation, mechanosensation, neurotransmission, and neurodegeneration. Earlier, we described the genetic association, within the Nuoro population, between Multiple Sclerosis (MS) and rs28936, located in ASIC2 3'UTR. Here we investigated the potential involvement of ASIC2 in MS inflammatory process. We induced experimental autoimmune encephalomyelitis (EAE) in wild-type (WT), knockout Asic1^-/- and Asic2^-/- mice and observed a significant reduction of clinical score in Asic1^-/- mice and a significant reduction in the clinical score in Asic2^-/- mice in a limited time window (i.e., at days 20-23 after immunization). Immunohistochemistr

SUBMITTER: Fazia T 

PROVIDER: S-EPMC6618268 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature