IL-2 therapy preferentially expands adoptively transferred donor-specific Tregs improving skin allograft survival.

ABSTRACT: Regulatory T cells (Tregs) have unique immunosuppressive properties and are essential to ensure effective immunoregulation. In animal models, Tregs have been shown to prevent autoimmune disorders and establish transplantation tolerance. Therefore, the prospect of harnessing Tregs, either by increasing their frequency or by conferring allospecificity, has prompted a growing interest in the development of immunotherapies. Here, employing a well-established skin transplant model with a single major histocompatibility complex mismatch, we compared the therapeutic efficacy of adoptively transfer Treg with or without donor specificity and the administration of IL-2 to promote in vivo expansion of Treg. We showed that IL-2 treatment preferentially enhances the proliferation of the allospecific Tr

SUBMITTER: Ratnasothy K 

PROVIDER: S-EPMC6618286 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature