Effectiveness of a Bundled Intervention Including Adjunctive Corticosteroids on Outcomes of Hospitalized Patients With Community-Acquired Pneumonia: A Stepped-Wedge Randomized Clinical Trial.

ABSTRACT:

Importance

Community-acquired pneumonia remains a leading cause of hospitalization, mortality, and health care costs worldwide. Randomized clinical trials support the use of adjunctive corticosteroids, early progressive mobilization, antibiotic switching rules, and dietary interventions in improving outcomes. However, it is uncertain whether implementing these interventions will translate into effectiveness under routine health care conditions.

Objective

To evaluate the effectiveness of a bundle of evidence-supported treatments under conditions of routine care in a representative population hospitalized for community-acquired pneumonia.

Design, setting, and participants

A double-blind, stepped-wedge, cluster-randomized clinical trial with 90-day follow-up was conducte

SUBMITTER: Lloyd M 

PROVIDER: S-EPMC6618815 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature