Human milk oligosaccharides promote immune tolerance via direct interactions with human dendritic cells.

ABSTRACT: Human milk oligosaccharides (HMOS) are a complex mixture of bioactive components supporting the immune development of breastfed-infants. Dendritic cells (DCs) play a central role in the regulation of immune responses, being specialized in antigen presentation and driving T-cell priming as well as differentiation. However, little is known about the direct effects of HMOS on human DC phenotypes and functions. Here, we report that HMOS mixture isolated from pooled human milk, induced semi-maturation of human monocytes-derived DCs (moDCs), and elevated levels of IL-10, IL-27 and IL-6 but not IL-12p70 and TNF-α. Consistently, HMOS-conditioned human moDCs promoted Treg generation from naïve CD4⁺ T cells. Interestingly, HMOS limited LPS-induced maturation of human moDCs, while maintain

SUBMITTER: Xiao L 

PROVIDER: S-EPMC6619030 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature