Radiosynthesis of the norepinephrine transporter tracer [¹⁸ F]NS12137 via copper-mediated ¹⁸ F-labelling.

ABSTRACT: [¹⁸ F]NS12137 (exo-3-[(6-[¹⁸ F]fluoro-2-pyridyl)oxy]8-azabicyclo[3.2.1]octane) is a highly selective norepinephrine transporter (NET) tracer. NETs are responsible for the reuptake of norepinephrine and dopamine and are linked to several neurodegenerative and neuropsychiatric disorders. The aim of this study was to develop a copper-mediated ¹⁸ F-fluorination method for the production of [¹⁸ F]NS12137 with straightforward synthesis conditions and high radiochemical yield and molar activity. [¹⁸ F]NS12137 was produced in two steps. Radiofluorination of [¹⁸ F]NS12137 was performed via a copper-mediated pathway starting with a stannane precursor and using [¹⁸ F]F^- as the source of the fluorine-18 isotope. De

SUBMITTER: Lahdenpohja S 

PROVIDER: S-EPMC6619244 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature