Age-related changes in the ease of dynamical transitions in human brain activity.

ABSTRACT: Executive functions, a set of cognitive processes that enable flexible behavioral control, are known to decay with aging. Because such complex mental functions are considered to rely on the dynamic coordination of functionally different neural systems, the age-related decline in executive functions should be underpinned by alteration of large-scale neural dynamics. However, the effects of age on brain dynamics have not been firmly formulated. Here, we investigate such age-related changes in brain dynamics by applying "energy landscape analysis" to publicly available functional magnetic resonance imaging data from healthy younger and older human adults. We quantified the ease of dynamical transitions between different major patterns of brain activity, and estimated it for the default mode n

SUBMITTER: Ezaki T 

PROVIDER: S-EPMC6619404 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature