A modified two-compartment model for measurement of renal function using dynamic contrast-enhanced computed tomography.

ABSTRACT:

Objectives

To validate and adapt a modified two-compartment model, originally developed for magnetic resonance imaging, for measuring human single-kidney glomerular filtration rate (GFR) and perfusion using dynamic contrast-enhanced computed tomography (DCE-CT).

Methods

This prospective study was approved by the institutional review board, and written informed consent was obtained from all patients. Thirty-eight patients with essential hypertension (EH, n = 13) or atherosclerotic renal artery stenosis (ARAS, n = 25) underwent renal DCE-CT for GFR and perfusion measurement using a modified two-compartment model. Iothalamate clearance was used to measure reference total GFR, which was apportioned into single-kidney GFR by renal blood flow. Renal perfusion was also calculated u

SUBMITTER: Jiang K 

PROVIDER: S-EPMC6619810 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature