Charge-switchable polymeric complex for glucose-responsive insulin delivery in mice and pigs.

ABSTRACT: Glucose-responsive insulin delivery systems with robust responsiveness that has been validated in animal models, especially in large animal models, remain elusive. Here, we exploit a new strategy to form a micro-sized complex between a charge-switchable polymer with a glucose-sensing moiety and insulin driven by electrostatic interaction. Both high insulin loading efficiency (95%) and loading capacity (49%) can be achieved. In the presence of a hyperglycemic state, the glucose-responsive phenylboronic acid (PBA) binds glucose instantly and converts the charge of the polymeric moiety from positive to negative, thereby enabling the release of insulin from the complex. Adjusting the ratio of the positively charged group to PBA achieves inhibited insulin release from the complex under normogly

SUBMITTER: Wang J 

PROVIDER: S-EPMC6620100 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature