The difference in serum proteomes in schizophrenia and bipolar disorder.

ABSTRACT:

Background

Purpose of study is revealing significant differences in serum proteomes in schizophrenia and bipolar disorder (BD).

Results

Quantitative mass-spectrometry based proteomic analysis was used to quantify proteins in the blood serum samples after the depletion of six major blood proteins. Comparison of proteome profiles of different groups revealed 27 proteins being specific for schizophrenia, and 18 - for BD. Protein set in schizophrenia was mostly associated with immune response, cell communication, cell growth and maintenance, protein metabolism and regulation of nucleic acid metabolism. Protein set in BD was mostly associated with immune response, regulating transport processes across cell membrane and cell communication, development of neurons and oligodendrocyt

SUBMITTER: Smirnova L 

PROVIDER: S-EPMC6620192 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature