Production and characterization of no-carrier-added ¹⁶¹Tb as an alternative to the clinically-applied ¹⁷⁷Lu for radionuclide therapy.

ABSTRACT:

Background

¹⁶¹Tb is an interesting radionuclide for cancer treatment, showing similar decay characteristics and chemical behavior to clinically-employed ¹⁷⁷Lu. The therapeutic effect of ¹⁶¹Tb, however, may be enhanced due to the co-emission of a larger number of conversion and Auger electrons as compared to ¹⁷⁷Lu. The aim of this study was to produce ¹⁶¹Tb from enriched ¹⁶⁰Gd targets in quantity and quality sufficient for first application in patients.

Methods

No-carrier-added ¹⁶¹Tb was produced by neutron irradiation of enriched ¹⁶⁰Gd targets at nuclear research reactors. The ¹⁶¹Tb purification method was developed with the use of cation exchange (Sykam resin) and extraction c

SUBMITTER: Gracheva N 

PROVIDER: S-EPMC6620226 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature