Machine Perfusion and the Pancreas: Will It Increase the Donor Pool?

ABSTRACT:

Purpose of review

Pancreas transplantation enables complete patient independence from exogenous insulin administration and increases both patient survival and quality of life. Despite this, there has been a decline in pancreas transplantation for the past 20 years, influenced by changing donor demographics with more high-risk extended criteria (ECD) and donation after cardiac death (DCD) donors. This review discusses whether the advent of machine perfusion (MP), if extended to the pancreas, can increase the pool of suitable donor organs.

Recent findings

Hypothermic and normothermic MP, as forms of preservation deemed superior to cold storage for high-risk kidney and liver donor organs, have opened the avenue for translation of this work into the pancreas. Recent experimental

SUBMITTER: Hamaoui K 

PROVIDER: S-EPMC6620253 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature