Diagnostic assessment of foetal brain malformations with intra-uterine MRI versus perinatal post-mortem MRI.

ABSTRACT:

Purpose

To evaluate differences in diagnostic yield of intra-uterine foetal (iuMR) and post-mortem MRI (PMMR) for complex brain malformations, using autopsy as the reference standard.

Methods

In this retrospective, multicentre study spanning 2 years, we reviewed 13 terminated singleton pregnancies with a prenatal ultrasound finding of complex foetal cerebral abnormalities, referred for both iuMR and PMMR. The iuMR and PMMR studies of the brain were reported independently by two groups of radiologists, blinded to each other's reports. Descriptive statistics were used to compare differences in intracranial abnormalities with autopsy (and genetic testing, where present) as reference standard.

Results

The median gestational age at termination was 24.6 weeks (IQR 22-29) wi

SUBMITTER: Goergen SK 

PROVIDER: S-EPMC6620257 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature