Type 2 Diabetes: Multiple Genes, Multiple Diseases.

ABSTRACT:

Purpose of review

Type 2 diabetes (T2D), which accounts for the vast majority of diabetes cases, is essentially a diagnosis of exclusion in current clinical practice. Therefore, it is not surprising that T2D is heterogenous in terms of patients' clinical presentation, disease course, and response to treatment. This review summarizes published attempts to improve diabetes subclassification, with a particular focus on the role of genetics.

Recent findings

A handful of diabetes subclassification schemas have been proposed using clinical data (patient characteristics and laboratory values), with some subgroups associated with distinct management trends or complication risks. However, phenotypically driven classifications suffer from dependencies on time of variable measurement a

SUBMITTER: Udler MS 

PROVIDER: S-EPMC6620259 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature