Evaluation of the Structure of Myodural Bridges in an Equine Model of Ehlers-Danlos Syndromes.

ABSTRACT: Myodural bridges have been described in various species as connective tissue structures "bridging" small cranio-cervical muscles to the dura. Myodural bridges are thought to stabilize the dural sac during head and neck movements and promote cerebrospinal fluid motion; however, their role in neurological diseases has not yet been established. We report ultrasonographic visualization, necropsy, histopathologic and ultrastructural findings of myodural bridges in horses with hereditary equine regional dermal asthenia (HERDA), an equine model of Ehlers-Danlos syndromes. Five HERDA and 5 control horses were studied. Post-mortem examination and ultrasonographic studies (3 HERDA and 4 controls) demonstrated that the atlanto-occipital and atlanto-axial myodural bridges are dynamic structures "movin

SUBMITTER: McElroy A 

PROVIDER: S-EPMC6620297 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature