Novel gene regulatory networks identified in response to nitro-conjugated linoleic acid in human endothelial cells.

ABSTRACT: Endothelial cell (EC) dysfunction is a crucial initiation event in the development of atherosclerosis and is associated with diabetes mellitus, hypertension, and heart failure. Both digestive and oxidative inflammatory conditions lead to the endogenous formation of nitrated derivatives of unsaturated fatty acids (FAs) upon generation of the proximal nitrating species nitrogen dioxide (·NO₂) by nitric oxide (·NO) and nitrite-dependent reactions. Nitro-FAs (NO₂-FAs) such as nitro-oleic acid (NO₂-OA) and nitro-linoleic acid (NO₂-LA) potently inhibit inflammation and oxidative stress, regulate cellular functions, and maintain cardiovascular homeostasis. Recently, conjugated linoleic acid (CLA) was identified as the preferential FA substrate of nitrat

SUBMITTER: Lu H 

PROVIDER: S-EPMC6620647 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature