Mitochondrial angiotensin receptors and cardioprotective pathways.

ABSTRACT: A growing body of data provides strong evidence that intracellular angiotensin II (ANG II) plays an important role in mammalian cell function and is involved in the pathogenesis of human diseases such as hypertension, diabetes, inflammation, fibrosis, arrhythmias, and kidney disease, among others. Recent studies also suggest that intracellular ANG II exerts protective effects in cells during high extracellular levels of the hormone or during chronic stimulation of the local tissue renin-angiotensin system (RAS). Notably, the intracellular RAS (iRAS) described in neurons, fibroblasts, renal cells, and cardiomyocytes provided new insights into regulatory mechanisms mediated by intracellular ANG II type 1 (AT₁Rs) and 2 (AT₂Rs) receptors, particularly, in mitochondria and

SUBMITTER: Escobales N 

PROVIDER: S-EPMC6620675 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature