Mapping genetic modifiers of radiation-induced cardiotoxicity to rat chromosome 3.

ABSTRACT: Radiation therapy is used in ~50% of cancer patients to reduce the risk of recurrence and in some cases improve survival. Despite these benefits, doses can be limited by toxicity in multiple organs, including the heart. The underlying causes and biomarkers of radiation-induced cardiotoxicity are currently unknown, prompting the need for experimental models with inherent differences in sensitivity and resistance to the development of radiation-induced cardiotoxicity. We have identified the parental SS (Dahl salt-sensitive/Mcwi) rat strain to be a highly-sensitized model of radiation-induced cardiotoxicity. In comparison, substitution of rat chromosome 3 from the resistant BN (Brown Norway) rat strain onto the SS background (SS-3^BN consomic) significantly attenuated radiation-indu

SUBMITTER: Schlaak RA 

PROVIDER: S-EPMC6620678 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature