Role of endothelial NAD⁺ deficiency in age-related vascular dysfunction.

ABSTRACT: Age-related alterations in endothelium and the resulting vascular dysfunction critically contribute to a range of pathological conditions associated with old age. To develop therapies rationally that improve vascular health and thereby increase health span and life span in older adults, it will be essential to understand the cellular and molecular mechanisms contributing to vascular aging. Preclinical studies in model organisms demonstrate that NAD⁺ availability decreases with age in multiple tissues and that supplemental NAD⁺ precursors can ameliorate many age-related cellular impairments. Here, we provide a comprehensive overview of NAD⁺-dependent pathways [including the NAD⁺-using silent information regulator-2-like enzymes and poly(ADP-ribose

SUBMITTER: Csiszar A 

PROVIDER: S-EPMC6620681 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature