Evolutionary Stability of Salt Bridges Hints Its Contribution to Stability of Proteins.

ABSTRACT: The contribution of newly designed salt bridges to protein stabilization remains controversial even today. In order to solve this problem, we investigated salt bridges from two aspects: spatial distribution and evolutionary characteristics of salt bridges. Firstly, we analyzed spatial distribution of salt bridges in proteins, elucidating the basic requirements of forming salt bridges. Then, from an evolutionary point of view, the evolutionary characteristics of salt bridges as well as their neighboring residues were investigated in our study. The results demonstrate that charged residues appear more frequently than other neutral residues at certain positions of sequence even under evolutionary pressure, which are able to form electrostatic interactions that could increase the evolutionary

SUBMITTER: Ban X 

PROVIDER: S-EPMC6620738 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature