Regulatory dendritic cells: profiling, targeting, and therapeutic application.

ABSTRACT:

Purpose of review

There is currently increased focus on improved understanding of how dendritic cell tolerogenicity is determined and maintained, and on their therapeutic potential. We review recent progress in profiling of regulatory dendritic cells (DCreg), innovative approaches to enhancing dendritic cell tolerogenicity in situ, ex-vivo generation of DCreg and initial clinical testing of these cells in organ transplantation.

Recent findings

"Omics' studies indicate that the distinctive properties of DCreg are the result of a specific transcriptional program characterized by activation of tolerance-enhancing genes, rather than the retention of an immature state. In situ dendritic cell-directed targeting of nanovesicles bearing immune regulatory molecules can trigger in-viv

SUBMITTER: Thomson AW 

PROVIDER: S-EPMC6620776 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature