A Novel Role for Cathepsin S as a Potential Biomarker in Triple Negative Breast Cancer.

ABSTRACT: Cathepsin S (CTSS) has previously been implicated in a number of cancer types, where it is associated with poor clinical features and outcome. To date, patient outcome in breast cancer has not been examined with respect to this protease. Here, we carried out immunohistochemical (IHC) staining of CTSS using a breast cancer tissue microarray in patients who received adjuvant therapy. We scored CTSS expression in the epithelial and stromal compartments and evaluated the association of CTSS expression with matched clinical outcome data. We observed differences in outcome based on CTSS expression, with stromal-derived CTSS expression correlating with a poor outcome and epithelial CTSS expression associated with an improved outcome. Further subtype characterisation revealed high epithelial CTSS

SUBMITTER: Wilkinson RDA 

PROVIDER: S-EPMC6620839 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature