Early vedolizumab trough levels predict combined endoscopic and clinical remission in inflammatory bowel disease.

ABSTRACT:

Background

The relationship between vedolizumab trough levels and combined endoscopic and clinical remission is unknown.

Objective

To compare vedolizumab trough levels in patients with and without combined remission within the first year of treatment.

Methods

We prospectively collected vedolizumab trough levels in 51 consecutive patients (28 Crohn's disease (CD) and 23 ulcerative colitis (UC)) before all infusions up to week 22, and at weeks 38 and 54, with concentrations measured after study completion. Centrally read endoscopy was performed at a median of 46 weeks. The primary outcome was combined endoscopic (CD: Simple endoscopic score for CD (SES-CD) < 4 without ulceration; UC: Mayo endoscopic subscore ≤ 1) and clinical remission (CD: resolution of abdominal pain;

SUBMITTER: Hanzel J 

PROVIDER: S-EPMC6620872 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature