Contribution of gut microbiota to metabolism of dietary glycine betaine in mice and in vitro colonic fermentation.

ABSTRACT:

Background

Accumulating evidence is supporting the protective effect of whole grains against several chronic diseases. Simultaneously, our knowledge is increasing on the impact of gut microbiota on our health and on how diet can modify the composition of our bacterial cohabitants. Herein, we studied C57BL/6 J mice fed with diets enriched with rye bran and wheat aleurone, conventional and germ-free C57BL/6NTac mice on a basal diet, and the colonic fermentation of rye bran in an in vitro model of the human gastrointestinal system. We performed 16S rRNA gene sequencing and metabolomics on the study samples to determine the effect of bran-enriched diets on the gut microbial composition and the potential contribution of microbiota to the metabolism of a novel group of betainized compoun

SUBMITTER: Koistinen VM 

PROVIDER: S-EPMC6621954 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature