PTBP3 contributes to colorectal cancer growth and metastasis via translational activation of HIF-1α.

ABSTRACT:

Background

Colorectal cancer (CRC) remains the fourth most common cause of cancer-related mortality worldwide. We aimed to identify key molecules and signalling pathways mediating CRC growth and metastasis. Polypyrimidine tract-binding protein 3 (PTBP3) is a member of PTB family. A prooncogenic role for PTBP3 has also been discovered in several kinds of tumors. However, the expression and biological functions of the PTBP3 are still unknown in CRC.

Methods

We analysed the expression levels of PTBP3 using tissue microarray containing 568 CRC tissues and corresponding non-tumor adjacent tissues. The correlations between the PTBP3 expression level and clinicopathological features were evaluated using the chi-square test. The functional characterization for the role and molecular

SUBMITTER: Hou P 

PROVIDER: S-EPMC6622005 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature