Von Hippel-Lindau Acts as a Metabolic Switch Controlling Nephron Progenitor Differentiation.

ABSTRACT:

Background

Nephron progenitors, the cell population that give rise to the functional unit of the kidney, are metabolically active and self-renew under glycolytic conditions. A switch from glycolysis to mitochondrial respiration drives these cells toward differentiation, but the mechanisms that control this switch are poorly defined. Studies have demonstrated that kidney formation is highly dependent on oxygen concentration, which is largely regulated by von Hippel-Lindau (VHL; a protein component of a ubiquitin ligase complex) and hypoxia-inducible factors (a family of transcription factors activated by hypoxia).

Methods

To explore VHL as a regulator defining nephron progenitor self-renewal versus differentiation, we bred Six2-TGC^tg mice with VHL^lox/lox

SUBMITTER: Cargill K 

PROVIDER: S-EPMC6622426 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature