Ontology highlight
ABSTRACT:
SUBMITTER: Xue X
PROVIDER: S-EPMC6622450 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Xue Xufeng X Sun Yubing Y Resto-Irizarry Agnes M AM Yuan Ye Y Aw Yong Koh Meng KM Zheng Yi Y Weng Shinuo S Shao Yue Y Chai Yimin Y Studer Lorenz L Fu Jianping J
Nature materials 20180521 7
Classic embryological studies have successfully applied genetics and cell biology principles to understand embryonic development. However, it remains unresolved how mechanics, as an integral driver of development, is involved in controlling tissue-scale cell fate patterning. Here we report a micropatterned human pluripotent stem (hPS)-cell-based neuroectoderm developmental model, in which pre-patterned geometrical confinement induces emergent patterning of neuroepithelial and neural plate border ...[more]