Relationship between infarct size and serum uric acid levels during the acute phase of stroke.

ABSTRACT:

Introduction

Uric acid has gained considerable attention as a potential neuroprotective agent in stroke during the last decades, however, its role in the pathophysiology of ischemic stroke remains poorly understood. A serial evaluation of uric acid levels during the acute phase of stroke and its association with infarct size on magnetic resonance imaging is lacking.

Methods

We present a cohort study of 31 patients with ischemic stroke who were not candidates for thrombolysis according to current criteria at the time. We performed daily measurements of serum uric acid and total antioxidant capacity of plasma during the first week after symptoms onset and 30 days after. Infarct size was determined in the acute phase by a DWI sequence and the final infarct size with a control M

SUBMITTER: Fernandez-Gajardo R 

PROVIDER: S-EPMC6622494 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature