Circulating levels of PRO-C3 reflect liver fibrosis and liver function in HIV positive patients receiving modern cART.

ABSTRACT:

Background and aims

Although combined antiretroviral treatment (cART) has improved overall survival of HIV infected patients, liver fibrosis and liver related-mortality still constitute major challenges in HIV positive patients. Collagen accumulates in the liver during fibrogenesis. Recent studies showed that circulating levels of extracellular matrix (ECM) fragments might reflect degree of portal hypertension and fibrosis stage in liver disease. In this study, we analyzed the correlation between liver fibrosis assessed by Fibroscan and levels of the formation and degradation markers of type III and IV collagen in HIV positive patients receiving cART.

Methods

116 HIV positive patients (82.7% male, median age 47 years) were enrolled into the study. Liver stiffness and liver f

SUBMITTER: Dold L 

PROVIDER: S-EPMC6622522 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature