Genomic surveillance of invasive meningococcal disease in the Czech Republic, 2015-2017.

ABSTRACT:

Introduction

The study presents the results of the genomic surveillance of invasive meningococcal disease (IMD) in the Czech Republic for the period of 2015-2017.

Material and methods

The study set includes all available IMD isolates recovered in the Czech Republic and referred to the National Reference Laboratory for Meningococcal Infections in 2015-2017, a total of 89 Neissseria meningitidis isolates-from 2015 (n = 20), 2016 (n = 27), and from 2017 (n = 42). All isolates were studied by whole genome sequencing (WGS).

Results

Serogroup B (MenB) was the most common, followed by serogroups C, W, and Y. Altogether 17 clonal complexes were identified, the most common of which was hypervirulent complex cc11, followed by complexes cc32, cc41/44, cc269, and cc865. Over the

SUBMITTER: Krizova P 

PROVIDER: S-EPMC6622526 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature