Lycium Barbarum Polysaccharides Protect Retina in rd1 Mice During Photoreceptor Degeneration.

ABSTRACT:

Purpose

As an active component in wolfberry, lycium barbarum polysaccharides (LBP) are capable of protecting retinal neurons in several animal disease models. Here, we asked whether LBP rescues the retinal morphology and function in rd1 mouse, a photoreceptor fast-degenerating animal model of retinitis pigmentosa, and in particular focused on LBP's effects on the function of retinal ganglion cells (RGCs) during photoreceptor degeneration.

Methods

An equal volume of LBP or control vehicle was daily intraperitoneal (i.p.) injected in rd1 mice from postnatal day 4 (P4) to P14, P20, or P24 when photoreceptors completely degenerate. Immunostaining, electroretinogram (ERG), visual behavior tests and multielectrode array (MEA) recordings were assessed to determine the structure and

SUBMITTER: Liu F 

PROVIDER: S-EPMC6623178 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature