Telomere length: population epidemiology and concordance in Australian children aged 11-12 years and their parents.

ABSTRACT: OBJECTIVES:To (1) describe the epidemiology of child and adult telomere length, and (2) investigate parent-child telomere length concordance. DESIGN:Population-based cross-sectional study within the Longitudinal Study of Australian Children. SETTING:Assessment centres in seven major Australian cities and eight selected regional towns; February 2015 to March 2016. PARTICIPANTS:Of 1874 participating families, telomere data were available for analysis for 1206 children and 1343 parents, of whom 1143 were parent-child pairs. There were 589 boys and 617 girls; 175 fathers and 1168 mothers. OUTCOME MEASURES:Relative telomere length (T/S ratio), calculated by comparing telomeric DNA (T) level with the single copy (S) beta-globin gene in venous blood-derived genomic DNA by quantitative real-time P

SUBMITTER: Nguyen MT 

PROVIDER: S-EPMC6624044 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature