Gray matter microglial activation in relapsing vs progressive MS: A [F-18]PBR06-PET study.

ABSTRACT:

Objective

To determine the value of [F-18]PBR06-PET for assessment of microglial activation in the cerebral gray matter in patients with MS.

Methods

Twelve patients with MS (7 relapsing-remitting and 5 secondary progressive [SP]) and 5 healthy controls (HCs) had standardized uptake value (SUV) PET maps coregistered to 3T MRI and segmented into cortical and subcortical gray matter regions. SUV ratios (SUVRs) were global brain normalized. Voxel-by-voxel analysis was performed using statistical parametric mapping (SPM). Normalized brain parenchymal volumes (BPVs) were determined from MRI using SIENAX.

Results

Cortical SUVRs were higher in the hippocampus, amygdala, midcingulate, posterior cingulate, and rolandic operculum and lower in the medial-superior frontal gyrus an

SUBMITTER: Singhal T 

PROVIDER: S-EPMC6624145 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature