Androgen Receptor Expression and Breast Cancer Survival: Results From the Nurses' Health Studies.

ABSTRACT:

Background

Hormone receptor signaling is critical in the progression of breast cancers, although the role of the androgen receptor (AR) remains unclear, particularly for estrogen receptor (ER)-negative tumors. This study assessed AR protein expression as a prognostic marker for breast cancer mortality.

Methods

This study included 4147 pre- and postmenopausal women with invasive breast cancer from the Nurses' Health Study (diagnosed 1976-2008) and Nurses' Health Study II (1989-2008) cohorts. AR protein expression was evaluated by immunohistochemistry and scored through pathologist review and as a digitally quantified continuous measure. Hazard ratios (HR) and 95% confidence intervals (CI) of breast cancer mortality were estimated from Cox proportional hazards models, adjustin

SUBMITTER: Kensler KH 

PROVIDER: S-EPMC6624168 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature