Integrative genomic and transcriptomic analysis of genetic markers in Dupuytren's disease.

ABSTRACT:

Background

Dupuytren's disease (DD) is a fibroproliferative disorder characterized by thickening and contracting palmar fascia. The exact pathogenesis of DD remains unknown.

Results

In this study, we identified co-expressed gene set (DD signature) consisting of 753 genes via weighted gene co-expression network analysis. To confirm the robustness of DD signature, module enrichment analysis and meta-analysis were performed. Moreover, this signature effectively classified DD disease samples. The DD signature were significantly enriched in unfolded protein response (UPR) related to endoplasmic reticulum (ER) stress. Next, we conducted multiple-phenotype regression analysis to identify trans-regulatory hotspots regulating expression levels of DD signature using Genotype-Tissue Ex

SUBMITTER: Jung J 

PROVIDER: S-EPMC6624179 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature