Production of protein-based polymers in Pichia pastoris.

ABSTRACT: Materials science and genetic engineering have joined forces over the last three decades in the development of so-called protein-based polymers. These are proteins, typically with repetitive amino acid sequences, that have such physical properties that they can be used as functional materials. Well-known natural examples are collagen, silk, and elastin, but also artificial sequences have been devised. These proteins can be produced in a suitable host via recombinant DNA technology, and it is this inherent control over monomer sequence and molecular size that renders this class of polymers of particular interest to the fields of nanomaterials and biomedical research. Traditionally, Escherichia coli has been the main workhorse for the production of these polymers, but the methylotrophic yeas

SUBMITTER: Werten MWT 

PROVIDER: S-EPMC6624476 | biostudies-literature | 2019 Sep - Oct

REPOSITORIES: biostudies-literature