Identification of a PEST Sequence in Vertebrate K_IR2.1 That Modifies Rectification.

ABSTRACT: K_IR2.1 potassium channels, producing inward rectifier potassium current (I _K1 ), are important for final action potential repolarization and a stable resting membrane potential in excitable cells like cardiomyocytes. Abnormal K_IR2.1 function, either decreased or increased, associates with diseases such as Andersen-Tawil syndrome, long and short QT syndromes. K_IR2.1 ion channel protein trafficking and subcellular anchoring depends on intrinsic specific short amino acid sequences. We hypothesized that combining an evolutionary based sequence comparison and bioinformatics will identify new functional domains within the C-terminus of the K_IR2.1 protein, which function could be determined by mutation analysis. We determined PE

SUBMITTER: Qile M 

PROVIDER: S-EPMC6624654 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature